Topological GeometroDynamics is a modification of general relativity inspired by the conceptual problems related to the definitions of inertial and gravitational energy in general relativity. Topological geometrodynamics can be also seen as a generalization of super string models. Physical space-times are seen as four-dimensional surfaces in certain eight-dimensional space. The choice of this space is fixed by symmetries of the standard model so that geometrization of known classical fields and elementary particle quantum numbers results. The notion of many-sheeted space-time allows re-interpretation of the structures of perceived world in terms of macroscopic space-time topology. The generalization of the number concept based on fusion of real numbers and p-adic number fields implies a further generalization of the space-time concept allowing to identify space-time correlates of cognition and intentionality. Quantum measurement theory extended to a quantum theory of consciousness becomes an organic part of theory. A highly non-trivial prediction is the existence of a fractal hierarchy of copies of standard model physics with dark matter identified in terms of macroscopic quantum phases characterized by dynamical and quantized Planck constant. The book is a comprehensive overview and analysis of topological geometrodynamics as a mathematical and physical theory.