The Drug Hunters pdf epub mobi txt 電子書 下載2025
Dr. Donald R. Kirsch has been a drug hunter for thirty five years, holds twenty-four drug-related patents, has written more than fifty papers, has been a reviewer for prestigious journals, a director, research group leader, and chief science officer at Wyeth, Cyanamid, Squibb, and Cambria Pharmaceuticals, and currently teaches drug discovery at Harvard Extension School. He lives in Bedford, MA.
Ogi Ogas, PhD, is a professional science writer. He is the coauthor of A Billion Wicked Thoughts and Shrinks and has published articles in the Wall Street Journal, Boston Globe, Wired, Glamour, Seed, and Psychology Today. He lives in Boston, MA.
- 藥物
- 經濟,政治和曆史
- 科普
- 科學和心理學
- 製藥
- Medical
The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter.
The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery.
The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.
具體描述
讀後感
本书的作者唐纳德是一位有35年药物研发经验的“猎药师”，拥有24项与药物有关的专利，曾在惠氏、威尔士制药等多家公司担任领导、研究团队主管和首席科学家，目前在哈佛进修学校教授药物研发。 作者为我们讲述了很多优秀的猎药师的故事，他们在改变人类医学的重大药物的研发中起...
評分讲真，《猎药师》绝对是我近期读得最慢的一本书。虽然作者已经很努力在科普了，但通篇还是有很多类似重组单克隆抗体、链霉菌、磺胺酏剂这样的神仙词汇。而作者最幽默而不自知的地方在于，他很喜欢说“众所周知”。比如，“众所周知，肾上腺素有两种，一种叫α受体，一种叫β受...
評分在猎药的道路上没有捷径,科学进步当然是前提和基础，但更多是不断试错和说不清的运气。向所有猎药师致敬。 植物时代 植物动物之间的生死决斗——植物进化出毒素来保护自己不被昆虫动物吃掉。昆虫动物进化出抵御毒素的物质，如通过肝酶分解毒素，比如血脑屏障。 植物毒素对昆虫...
評分对于我这种门外汉非常好的普及读物，撇开技术细节谈研究思路。作者回顾了人类千年发现/发明新药的历史：首先是植物时代，直接服用天然植物而不加考虑有效成分，代表是鸦片和金鸡纳霜；第二是19世纪中叶开始的工业化制药时代，大规模标准化生产已证明有药用效果的化学试剂，代表...
評分讲真，《猎药师》绝对是我近期读得最慢的一本书。虽然作者已经很努力在科普了，但通篇还是有很多类似重组单克隆抗体、链霉菌、磺胺酏剂这样的神仙词汇。而作者最幽默而不自知的地方在于，他很喜欢说“众所周知”。比如，“众所周知，肾上腺素有两种，一种叫α受体，一种叫β受...
用戶評價
很有意思的書，非常淺顯好讀。作為前化工工程師，能深刻體會drug hunter們的艱辛，而成藥上市的難度對比化工品的研發又是雲泥之彆瞭。運氣確實比智慧更重要。
评分很有意思的書，非常淺顯好讀。作為前化工工程師，能深刻體會drug hunter們的艱辛，而成藥上市的難度對比化工品的研發又是雲泥之彆瞭。運氣確實比智慧更重要。
评分很有意思的書，非常淺顯好讀。作為前化工工程師，能深刻體會drug hunter們的艱辛，而成藥上市的難度對比化工品的研發又是雲泥之彆瞭。運氣確實比智慧更重要。
评分很有意思的書，非常淺顯好讀。作為前化工工程師，能深刻體會drug hunter們的艱辛，而成藥上市的難度對比化工品的研發又是雲泥之彆瞭。運氣確實比智慧更重要。
评分很有意思的書，非常淺顯好讀。作為前化工工程師，能深刻體會drug hunter們的艱辛，而成藥上市的難度對比化工品的研發又是雲泥之彆瞭。運氣確實比智慧更重要。
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