Dr. Donald R. Kirsch has been a drug hunter for thirty five years, holds twenty-four drug-related patents, has written more than fifty papers, has been a reviewer for prestigious journals, a director, research group leader, and chief science officer at Wyeth, Cyanamid, Squibb, and Cambria Pharmaceuticals, and currently teaches drug discovery at Harvard Extension School. He lives in Bedford, MA.
Ogi Ogas, PhD, is a professional science writer. He is the coauthor of A Billion Wicked Thoughts and Shrinks and has published articles in the Wall Street Journal, Boston Globe, Wired, Glamour, Seed, and Psychology Today. He lives in Boston, MA.
The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter.
The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery.
The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.
讲真,《猎药师》绝对是我近期读得最慢的一本书。虽然作者已经很努力在科普了,但通篇还是有很多类似重组单克隆抗体、链霉菌、磺胺酏剂这样的神仙词汇。而作者最幽默而不自知的地方在于,他很喜欢说“众所周知”。比如,“众所周知,肾上腺素有两种,一种叫α受体,一种叫β受...
评分 评分 评分很有意思的书,非常浅显好读。作为前化工工程师,能深刻体会drug hunter们的艰辛,而成药上市的难度对比化工品的研发又是云泥之别了。运气确实比智慧更重要。
评分很有意思的书,非常浅显好读。作为前化工工程师,能深刻体会drug hunter们的艰辛,而成药上市的难度对比化工品的研发又是云泥之别了。运气确实比智慧更重要。
评分很有意思的书,非常浅显好读。作为前化工工程师,能深刻体会drug hunter们的艰辛,而成药上市的难度对比化工品的研发又是云泥之别了。运气确实比智慧更重要。
评分很有意思的书,非常浅显好读。作为前化工工程师,能深刻体会drug hunter们的艰辛,而成药上市的难度对比化工品的研发又是云泥之别了。运气确实比智慧更重要。
评分很有意思的书,非常浅显好读。作为前化工工程师,能深刻体会drug hunter们的艰辛,而成药上市的难度对比化工品的研发又是云泥之别了。运气确实比智慧更重要。
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