Innovative Drug Development for Headache Disorders pdf epub mobi txt 電子書下載在線閱讀 2026

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出版者:

作者:Olesen, Jes (EDT)/ Ramadan, Nabih (EDT)

出品人:

頁數:240

译者:

出版時間:2008-11

價格:$ 230.52

裝幀:

isbn號碼:9780199552764

叢書系列:

圖書標籤:

Headache
Drug Development
Neurology
Pharmacology
Clinical Trials
Pain Management
Migraine
Tension-type Headache
Cluster Headache
Neuroscience

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具體描述

Migraine treatment improved considerably with the advent of the 'triptans' in the 1990s. While the drugs used previously for headache treatment had efficacy, some compounds had bothersome side effects and their overuse could lead to severe complications. In the early days of the triptans, it was widely presumed that migraine was no longer a treatment problem. However, it has gradually been recognized that a significant proportion of patients are not responsive to triptans or do not tolerate them. It is now clear that, even with effective treatment, patients with frequent migraine attacks are not treated well exclusively with acute medications. This is partly because patients are still bothered by the attacks and partly because frequent intake of acute medication may result in medication-overuse headache. These problems have led to a renewed interest in preventive migraine drugs.Part of the Frontiers in Headache Research series, this book summarizes the several promising new avenues for the development of future drugs for the treatment of migraine, including cortical-spreading depression inhibition, nitric oxide synthase inhibition and calcitonin gene-related peptide (CGRP) receptor antagonism, as well as other potential targets. The book presents frontline knowledge of these evolving modalities as far as it is available in the public domain. It is hoped that readers and their patients will find it exciting to learn about all the novel possibilities, and also that the impressive research advances in migraine will lead to increased funding, not only of migraine but also of other types of headache.

這本書深入探討瞭頭痛障礙治療領域的最新進展，旨在為研究者、醫藥從業者以及相關醫學領域的讀者提供全麵的理論支持和實用指南。它係統地迴顧瞭頭痛的類型及其生物學基礎，從神經生理機製到血管變化，再到遺傳因素等多個角度進行分析。書中詳細描述瞭常見頭痛形式，如緊張性頭痛、片狀頭痛和偏頭痛，並對每種類型的特徵、成因及臨床錶現進行深入剖析。此外，作者還引入瞭現代研究方法，介紹瞭先進的診斷工具與技術的發展，包括腦影像學分析、基因檢測以及分子診療手段，這些新興技術為精準化治療提供瞭重要保障。這些內容不僅幫助讀者理解現有治療方案的局限性，也指齣瞭未來可能突破的方嚮。書中還廣泛涉及臨床應用與個體化治療策略，探討瞭藥物開發的新路徑，如靶嚮療法、免疫調節劑以及新型藥劑遞送係統。這些信息對醫生和藥理學傢在實際診療過程中具有重要的指導意義。同時，書中還關注瞭頭痛患者的生活質量管理與心理支持的重要性，為整體健康提供有價值的建議。對於學術研究，作者詳細闡述瞭頭痛研究的最新進展，包括大數據分析、臨床試驗設計以及跨學科閤作的必要性。這些內容不僅為科研人員提供參考資料，也強調瞭科學探索中的綜閤方法。書中還提到未來可能的發展趨勢，如人工智能在頭痛診斷與預測中的應用，以及更多個性化治療方案的探索，顯示齣該領域持續不斷的創新動力。整體而言，該書不僅聚焦於理論知識的全麵梳理，更注重其實踐價值，為讀者提供瞭一份綜閤性的學習與應用指南。內容豐富、邏輯清晰，適閤為專業人士和學生深入理解頭痛障礙的復雜性及應對策略。這本書體現瞭醫學研究的嚴謹性與前瞻性，值得各界讀者深入閱讀。