Biological resource centres (BRCs) collect, certify and distribute organisms for use in research and in the development of commerical products in the pharmaceutical, agricultural and biotechnology industries. They maintain a large and varied collection, including cell lines, micro-organisms, recombinant DNA material, biological media and reagents, and the information technology tools that allow researchers to access biological materials. BRCs have established themselves as a crucial element in the life science innovation infrastructure, from their early impact on virology to their crucial role in addressing cross-culture contamination in the 1970s to their current leadership in promoting a global biodiversity network. They confront new challenges, resulting from shifts in the nature of biological research, the interaction between public and private researchers and the increasing focus on biosecurity. This volume offers a systematic economic assessment of the impact of biological resource centres through their role in facilitating cumulative knowledge in the life sciences and building on their roles as knowledge hubs - institutions that facilitate the transfer of scientific and technical knowledge among members of a research community. The knowledge hubs framework offers insight into how to develop and evaluate policy proposals that impinge on the control and access of biological materials. Stern argues that science and innovation policy must be premised on a clear understanding of the role that knowledge hubs play and the policy mechanisms that encourage their sustained growth and effectiveness.