This compact, graduate-level text focuses on a key area of biophysical chemistry. "Introduction to Macromolecular Binding Equilibria" starts with a description of the features of binding sites for small molecules and then presents a discussion of the formulation of binding isotherms for simple mathematical models. The book addresses special problems of describing isotherms for linear polymers and examines the complications of binding cooperativity and thermodynamic linkage interactions among multiple ligands. Important aspects of experimental designs are highlighted along with methods for model-free analysis of data to reveal the binding isotherm. The author also covers ligand binding to planar arrays of sites.
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