Skeletal Development and Remodeling in Health, Disease and Aging pdf epub mobi txt 電子書下載在線閱讀 2026

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出版者:Blackwell Pub

作者:Zaidi, Mone 編

出品人:

頁數:452

译者:

出版時間:2006-7

價格:$ 154.95

裝幀:Pap

isbn號碼:9781573315838

叢書系列:

圖書標籤:

骨骼發育
骨骼重塑
骨骼健康
骨骼疾病
衰老
骨代謝
骨生物學
骨骼生理學
骨密度
骨質疏鬆癥

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具體描述

Our understanding of how the skeleton is remodeled and repaired has been enormously expanded in the past decade. Using advanced molecular technologies including transgenesis, gene knockout, and gene array, we are gaining a better understanding of both the precise pathways through which osteoblasts lay down new bone and how osteoclasts remove old bone. These studies have not only helped us understand the basic biological properties of the skeleton and how it responds to hormonal, cytokine, and mechanical stimulation, but also, in some instances, clarified the source of pathophysiology. The eventual goal of such discoveries is to lay down a firm scientific foundation for the identification of novel cellular and molecular targets for future drug development. This volume presents the significant headway that scientists have made in this undertaking and the book is organized around four broad themes: skeletal development and repair, molecular endocrinology of bone, bone cell biology, and conservation of skeletal integrity. Also included are papers that focus on current and emerging therapies for osteoporosis. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

該書係統地探討瞭骨骼發育與重塑的多方麵動態過程，旨在全麵揭示這一領域在健康、疾病和老齡化中的關鍵作用。內容聚焦於骨組織從形成到持續更新的完整生物學路徑，詳細描繪瞭成骨細胞與破骨細胞之間精密的相互作用，這些細胞通過分化、增殖及其周期性活躍，共同維持骨骼的強度和結構穩態。書中深入分析瞭激素調控機製，如雌激素、維生素D及類固醇等，其在調節骨代謝平衡中的核心地位，揭示瞭這些信號分子如何在不同生命階段對骨健康産生深遠影響。還特彆關注瞭多種疾病狀態下的骨骼變化，為理解骨質疏鬆、骨關節炎及其他相關病理提供科學依據。通過係統迴顧經典與最新研究，書揭示瞭骨重塑過程在生理需求與病理環境中的差異性錶現，為臨床診斷和治療策略的優化奠定基礎。讀者將能清晰認識骨骼動態變化的分子機製，並理解其對生活質量和疾病預防的重要性。本書還詳細闡述瞭當代技術如何推動研究進展，如高分辨率成像、基因編輯工具以及多組學整閤分析方法，這些技術不僅加深瞭對骨骼發育機製的理解，也為未來精準醫療和個性化乾預提供瞭技術支撐。通過大量圖錶和實例，內容生動地展示瞭復雜生物過程與實際應用之間的橋梁，確保讀者能夠全麵掌握骨骼科學領域的重要知識點。這篇書不僅適閤學術研究人員，也為跨學科學習者提供瞭豐富有價值的知識框架。總體而言，本書以嚴謹且深入的視角梳理瞭骨骼發育與重塑的科學脈絡，旨在為讀者構建一個完整、可靠的理論體係。這種細緻的內容安排有助於讀者係統理解這一復雜領域，同時也強調瞭骨健康維護和疾病防治的重要性。通過豐富的實例分析與最新研究成果的呈現，該書期望在學術界以及公眾教育中發揮重要作用，提升整體對骨骼生物學的認知水平。