Introduction to the Cellular and Molecular Biology of Cancer

Introduction to the Cellular and Molecular Biology of Cancer pdf epub mobi txt 电子书 下载 2026

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出版者:Oxford University Press 作者:Knowles, Margaret A./ Selby, Peter J. 出品人: 页数:552 译者: 出版时间:2005-9-15 价格:USD 101.00 装帧:Paperback isbn号码:9780198525639 丛书系列:
图书标签
  • Cancer Biology
  • Molecular Biology
  • Cell Biology
  • Oncology
  • Genetics
  • Biochemistry
  • Medicine
  • Research
  • Textbook
  • Education
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具体描述

This new edition o Introduction and Molecular Biology of Cancer provides a concise yet comprehensive overview of cancer biology, covering the current status of both research and treatment. For the student or new researcher the breadth of cancer research can appear daunting, yet a broad understanding is essential for translation of laboratory findings into the clinic.

Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field, and the accompanying bibliographies allow rapid access to the relevant current literature. The book covers topics extending from the molecular alterations found in cancer cells and their causes to the current range of approaches to treatment. Since the publication of the previous edition in 1997 there has been unprecedented progress in cancer research: this is reflected by an extensive revision of all the material, and the addition of eight new chapters, covering DNA repair, epigenetic events, the cell cycle, cell immortalization, apoptosis, angiogenesis, animal models, the genome, transcriptome and proteome, radiotherapy and molecular radiotherapy, immunotherapy, and gene therapy. The fourth edition of the popular book will serve as a text for both undergraduate and postgraduate use and also as an introduction for clinicians and scientists new to the field.

这本书以深入浅出的视角,系统阐述了细胞生物学与分子生物学在癌症研究中的核心作用。其内容围绕着癌症发源、机制及其与细胞信号传导、基因表达调控之间复杂关系展开。作者详细解析了肿瘤的起源过程,特别强调了突变积累与环境因素如何共同驱动疾病的发展。这一书不仅覆盖了传统癌症类型的基本概念,还深入探讨了不同分子机制在特定癌症中的具体表现,如DNA修复缺陷、细胞周期控制失调和凋亡抑制等。 在内容结构上,书中采用逻辑清晰的章节安排,首先介绍细胞生物学与分子生物学的基础理论,然后逐步引入癌症相关的关键概念,如基因突变、表观遗传调控和代谢重编程。每一章均配有大量图示和实验案例,使复杂的科学内容更加直观易懂。书中还特别注重对患者预后与治疗策略的分析,帮助读者理解理论知识在实际医疗中的应用前景。 作者通过综合多领域数据,系统梳理了癌症发生发展的时间轴,从细胞分裂错误、基因组不稳定性到肿瘤微环境的动态变化,全方位解释疾病的进程。这种全面覆盖不仅增强了科学严谨性,也使读者能够清晰把握癌症研究的宏观脉络。书中还特别强调了跨学科合作的重要性,探讨了基因组学、蛋白质工程和药物开发等前沿方向,为读者提供了未来科研与临床应用的思路。 此外,该书注重理论与实践的结合,详细描述了各类实验技术在癌症研究中的应用,如高通量测序、CRISPR基因编辑及免疫治疗技术。这些内容不仅帮助读者理解基础科学,还为实际科研提供了可操作性方案。书中还包含大量参考文献和最新研究进展,确保信息的时效性与权威性。 整个书籍以学术严谨的态度展现了细胞生物学与分子生物学在癌症领域的重要意义,通过系统性的知识传授,旨在培养读者对生命科学前沿的敏锐洞察。这些内容经过精心整理,不仅丰富了对癌症本质的理解,也为医学研究和患者诊疗提供了坚实基础。无论是学生还是科研人员,这本书都具备重要的学习与参考价值,全面而深入地揭示了生命的复杂机制。

作者简介

Margaret Knowles is Professor of Experimental Cancer Research at the University of Leeds, and Associate Director of the Cancer Research UK Clinical Centre, also in Leeds. Peter Selby is Professor of Cancer Medicine and Director of the National Cancer Research Network at the University of Leeds.

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