The Horizon Scientific Press titles focus on high-level microbiology and molecular biology topics. Written by internationally renowned and highly respected leaders in the field, they comprise of review manuals, practical manuals, and reference texts for research scientists, bioscience professionals and graduate students. Generations of new vaccines such as DNA-based vaccines, multipeptide, lipopeptide, molecular, cellular and replicon-based vaccines are currently being developed to help combat viral, bacterial, and parasitic infections, and non-infectious diseases including cancer, autoimmune diseases, allergies, neurodegenerative and metabolic diseases. In this book, internationally acclaimed authors review current strategies and approaches in vaccine development. Topics covered include the immunological basis for rational design of new vaccines, targeting the innate immune system, mucosal immunity, vaccine safety, and vaccine vector technology. Several chapters are devoted to the development of vaccines to combat specific diseases such as tuberculosis, nosocomal infections, rotaviruses, human papillomavirus, cancer, and allergies. This is an essential reference book for everyone involved in vaccine research and development.